Research - CARE II

CARE II

Brief introduction:

The study of Chinese Atherosclerosis Risk Evaluation (CARE-II, NCT02017756, 2012-2015) is a cross-sectional, multicenter, observational study. The primary objective of CARE-II study is to investigate the prevalence of high-risk carotid atherosclerotic plaques in Chinese patients with carotid plaque determined by ultrasound and recent cerebrovascular symptoms using multicontrast MR vessel wall imaging. We recruited subjects from 14 imaging sites across China and performed carotid artery MR imaging with identical imaging protocol and dedicated carotid coil. The key finding of this study is that the prevalence of carotid high-risk plaque is significantly higher than >50% stenosis (28% vs. 19%, p <0.0001) in Chinese symptomatic patients.

Publications:

1. Gao X, Song J, Watase H, Hippe DS, Zhao X, Canton G, Tian F, Du R, Ji S, Yuan C. Differences in Carotid Plaques Between Symptomatic Patients With and Without Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2019 Jun.
2. Zhou C, Yuan C, Li R, Wang W, Li C, Zhao X; CARE-II Study Collaborators. Association Between Incomplete Circle of Willis and Carotid Vulnerable Atherosclerotic Plaques. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2744-2749.
3. Zhao X, Li R, Hippe DS, Hatsukami TS, Yuan C; CARE-II Investigators. Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events-design and rationale. Stroke Vasc Neurol. 2017 Feb 24;2(1):15-20.
4. Zhao X, Hippe DS, Li R, Canton GM, Sui B, Song Y, Li F, Xue Y, Sun J, Yamada K, Hatsukami TS, Xu D, Wang M, Yuan C; CARE‐II Study Collaborators. Prevalence and Characteristics of Carotid Artery High-Risk Atherosclerotic Plaques in Chinese Patients With Cerebrovascular Symptoms: A Chinese Atherosclerosis Risk Evaluation II Study. J Am Heart Assoc. 2017 Aug 14;6(8). pii: e005831.
5. Wang X, Sun J, Zhao X, Hippe DS, Hatsukami TS, Liu J, Li R, Canton G, Song Y, Yuan C; CARE-II study investigators. Ipsilateral plaques display higher T1 signals than contralateral plaques in recently symptomatic patients with bilateral carotid intraplaque hemorrhage. Atherosclerosis. 2017 Feb;257:78-85.
6. Luo L, Liu S, Tong X, Jiang P, Yuan C, Zhao X, Shang F. Carotid artery segmentation using level set method with double adaptive threshold (DATLS) on TOF-MRA images. Magn Reson Imaging. 2019 Nov.
7. Watase H, Canton G, Sun J, Zhao X, Hatsukami TS, Yuan C. Four Different Carotid Atherosclerotic Behaviors Based on Luminal Stenosis and Plaque Characteristics in Symptomatic Patients: An in Vivo Study. Diagnostics (Basel). 2019 Oct 2.
8. Liu Y, Wang M, Zhang B*, Wang W, Xu Y, Han Y, Yuan C, Zhao X*. Size of carotid artery intraplaque hemorrhage and acute ischemic stroke: a cardiovascular magnetic resonance Chinese atherosclerosis risk evaluation study. J Cardiovasc Magn Reson. 2019 Jul 1.
9. Gao X, Song J, Watase H, Hippe DS, Zhao X*, Canton G, Tian F, Du R, Ji S*, Yuan C. Differences in Carotid Plaques Between Symptomatic Patients With and Without Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2019 Jun.